pim kinases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0201	Hispidulin	Dinatin	Pim
	Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).		Pim
T8114	Quercetagetin	6-Hydroxyquercetin	Pim
	Quercetagetin (6-Hydroxyquercetin) (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50: 0.34 μM).		Pim
T4523	TP-3654		Pim
	TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).		Pim
T3058	(Z)-SMI-4a	TCS PIM-1 4a,SMI-4a	Pim
	(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.		Pim
T2300	AZD1208		Apoptosis , Pim , Autophagy
	AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.		Apoptosis , Pim , Autophagy
T1834	CX-6258	CX 6258	Pim
	CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.		Pim
T3078	SGI-1776	SGI-1776 free base,Pim-Kinase Inhibitor IX	Apoptosis , FLT , Pim , Autophagy
	SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.		Apoptosis , FLT , Pim , Autophagy
T6148	CX-6258 hydrochloride	CX-6258 HCl,Pim-Kinase Inhibitor X	Pim
	CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).		Pim
T3989	SMI-16a	PIM1/2 Kinase Inhibitor VI	Pim
	SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against...		Pim
T2253	TCS PIM-1 1	SC 204330	Pim
	TCS PIM-1 1 (SC 204330)(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >20, 000 nM).		Pim
T5093	Pim1/AKK1-IN-1	LKB1/AAK1 dual inhibitor,MDK-2275	Pim , Hippo pathway
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.		Pim , Hippo pathway
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T12477	Uzansertib phosphate	INCB053914 phosphate	Pim
	Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).		Pim
T15376	GDC-0339		Pim
	GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of pan-Pim kinase (Kis: 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respective...		Pim
T9229	Pim-1/2 kinase inhibitor 1		Pim
	Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides. It particularly inhibits the phosphorylation of 4E-BP1 and p27 Kip1 by Pim ...		Pim
T15830	M-110		Pim
	M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 μM. M-110 inhibits the proliferation of prostate ca...		Pim
T27704	K00135	K-00135,Imidazol[1,2-b]pyridazine 1,K 00135,IMIDAZOPYRIDAZIN 1	Pim
	K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.		Pim
T71558	Pim-IN-14j
	Pim-IN-14j is a potent, highly selective, and orally bioavailable inhibitor of PIM-1 kinases.
T71227	LGB-321 HCl
	LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). LGB321 is unique relative to previously described PIM inhibitors, in that it is active in PIM2 depende...
T81460	PIM-IN-2		Pim
	PIM-IN-2 (Pim-2) is a potent inhibitor of Pim kinases, demonstrating an inhibition concentration half-maximal (IC50) value of 25 nM . It exhibits antiapoptotic properties conducive to cell survival and has been found to ...		Pim